Document Detail


Synthesis and anticonvulsant activity of amino acid-derived sulfamides.
MedLine Citation:
PMID:  19249853     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sulfamides are promising functions for the design of new antiepileptic drugs ( Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614 ). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimental data confirmed the ability of some of the structures to suppress the convulsions originated by the electrical seizure (MES test) at low doses (100 mg/kg).
Authors:
Luciana Gavernet; Juan E Elvira; Gisela A Samaja; Valentina Pastore; Mariana Sella Cravero; Andrea Enrique; Guillermina Estiu; Luis E Bruno-Blanch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  52     ISSN:  1520-4804     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-19     Completed Date:  2009-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1592-601     Citation Subset:  IM    
Affiliation:
Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, 47 and 115, La Plata B1900BJW, Argentina. lgavernet@biol.unlp.edu.ar
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MeSH Terms
Descriptor/Qualifier:
Amides / chemical synthesis*,  chemistry,  pharmacology*
Anticonvulsants / chemical synthesis*,  chemistry,  pharmacology*
Magnetic Resonance Spectroscopy
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Amides; 0/Anticonvulsants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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