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Synthesis, anticandidal activity and cytotoxicity of some tetrazole derivatives.
MedLine Citation:
PMID:  23323990     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract In this study, 14 different 2-[(1-methyl-1H-tetrazole-5-yl)thio]-1-(phenyl)ethanone derivatives (1-14) were synthesized. The structures of the obtained compounds were elucidated using IR, (1)H-NMR, (13)C-NMR and FAB(+)-MS spectral data and elemental analyses results. The compounds were screened for their anticandidal activity using the microbroth dilution method and for their cytotoxic effects using the MTT assay against NIH/3T3 cells. Some of the compounds were found to be potent anticandidal agents with weak cytotoxicities.
Authors:
Zafer Asim Kaplancikli; Leyla Yurttaş; Ahmet Ozdemir; Gülhan Turan-Zitouni; Gökalp Işcan; Gülşen Akalın; Usama Abu Mohsen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Journal of enzyme inhibition and medicinal chemistry     Volume:  -     ISSN:  1475-6374     ISO Abbreviation:  J Enzyme Inhib Med Chem     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101150203     Medline TA:  J Enzyme Inhib Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pharmaceutical Chemistry, Graduate School of Health Sciences, Anadolu University , Eskisehir , Turkey .
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