Document Detail

Synthesis and anticandidal activities of optimized analogs of antibiotic Sch 37137.
MedLine Citation:
PMID:  8040077     Owner:  NLM     Status:  MEDLINE    
Peptide analogues of Sch 37137 the antifungal antibiotic have been synthesized and evaluated in vitro against Candida sp. Di- and tripeptides containing methionine, leucine, norvaline, lysine, glutamic acid and N3-(trans-epoxysuccinamoyl)-L-2,3-diaminopropanoic acid, (EADP) were obtained. Peptides containing (D)-, and (L)-trans-epoxysuccinamic acid were also prepared. All of the analogues examined displayed in general higher anticandidal activity than a mixture of diastereomers of Sch 37137.
R Andruszkiewicz; T Zieniawa; H Chmara; L Kasprzak; E Borowski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  47     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-08-22     Completed Date:  1994-08-22     Revised Date:  2012-11-06    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  715-23     Citation Subset:  IM    
Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, Poland.
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MeSH Terms
Amino Acids, Diamino / chemistry,  pharmacology
Antifungal Agents / chemistry,  pharmacology*
Candida / drug effects*
Magnetic Resonance Spectroscopy
Structure-Activity Relationship
Reg. No./Substance:
0/Amino Acids, Diamino; 0/Antifungal Agents; 113737-67-0/N-L-alanyl-3-(((3-(aminocarbonyl)oxiranyl)carbonyl)amino)-L-alanine

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