Document Detail

Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles.
MedLine Citation:
PMID:  16714116     Owner:  NLM     Status:  MEDLINE    
Four classes of UK-1 analogues were synthesized and their cytotoxicity testing against human A-549, BFTC-905, RD, MES-SA, and HeLa carcinoma cell lines was determined. The results revealed that UK-1 and four of these analogues (15-18) are potent against the cancer cell lines. In particular, compound 16 is more potent than UK-1 against A-549 and HeLa cell lines, and compounds 15, 17, and 18 selectively exhibit potent cytotoxic activity against the BFTV-905 cells (IC50 9.6 microM), A-549 cells (IC50 6.6 microM), and MES-SA cells (IC50 9.2 microM), respectively.
Shu-Ting Huang; I-Jen Hsei; Chinpiao Chen
Related Documents :
15698766 - Sar studies of brasilicardin a for immunosuppressive and cytotoxic activities.
20172046 - Particulate depleted uranium is cytotoxic and clastogenic to human lung epithelial cells.
3217946 - Distinguishing features of cytotoxic and pharmacological effects of selenite in murine ...
12727276 - Cytotoxic and cytostatic activity of erlangerins from commiphora erlangeriana.
22964256 - Cell envelope stress response in cell wall-deficient l-forms of bacillus subtilis.
8846796 - Endoplasmic reticulum-to-cytosol transport of free polymannose oligosaccharides in perm...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-22
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  14     ISSN:  0968-0896     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-07-25     Completed Date:  2006-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  6106-19     Citation Subset:  IM    
Department of Chemistry, National Dong Hwa University, Shoufeng, Hualien 974, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Benzimidazoles / chemical synthesis*,  chemistry,  pharmacology*
Benzothiazoles / chemical synthesis*,  chemistry,  pharmacology*
Benzoxazoles / chemical synthesis*,  chemistry,  pharmacology*
Cell Line, Tumor
Molecular Structure
Neoplasms / drug therapy,  pathology*
Reg. No./Substance:
0/Benzimidazoles; 0/Benzothiazoles; 0/Benzoxazoles

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  QSAR analysis of antimicrobial and haemolytic effects of cyclic cationic antimicrobial peptides deri...
Next Document:  Luminescent pyrimidine hydrazide oligomers with peptide affinity.