| Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites. | |
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MedLine Citation:
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PMID: 18175003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new series of geldanamycin derivatives were synthesized using a semi-synthetic approach involving genetically engineered biosynthetic intermediates. These analogues were then evaluated for anti-proliferation activity in human cancer cell lines, SK-Br3 and SK-Ov3. Most of the synthesized compounds exhibited potent in vitro anti-proliferation activity toward both cell lines. Such compounds potently inhibited the expression of the Hsp90 client protein ErbB2. |
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Authors:
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Kyeong Lee; Jung S Ryu; Yinglan Jin; Woncheol Kim; Navneet Kaur; Sang J Chung; Yong-Jin Jeon; Joon-Tae Park; Ji S Bang; Hong S Lee; Tae Y Kim; Jung J Lee; Young-Soo Hong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-30 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: 6 ISSN: 1477-0520 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-04 Completed Date: 2008-04-03 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: England |
Other Details:
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Languages: eng Pagination: 340-8 Citation Subset: IM |
Affiliation:
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Korea Research Institute of Bioscience & Biotechnology, 52 Eoeundong, Yuseonggu, Daejeon, 305-806, Korea. kaylee@kribb.re.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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chemical synthesis*,
chemistry,
pharmacology* Benzoquinones / chemical synthesis*, chemistry, pharmacology* Cell Line, Tumor Cell Proliferation / drug effects* Drug Screening Assays, Antitumor Genetic Engineering HSP90 Heat-Shock Proteins / antagonists & inhibitors Humans Lactams, Macrocyclic / chemical synthesis*, chemistry, pharmacology* Molecular Conformation Receptor, erbB-2 / antagonists & inhibitors Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Benzoquinones; 0/HSP90 Heat-Shock Proteins; 0/Lactams, Macrocyclic; 30562-34-6/geldanamycin; EC 2.7.10.1/ERBB2 protein, human; EC 2.7.10.1/Receptor, erbB-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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