Document Detail


Synthesis and anticancer activity evaluation of 3,4-mono- and bicyclosubstituted N-(het)aryl trifluoromethyl succinimides.
MedLine Citation:
PMID:  25400294     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Novel trifluoromethylated mono- and bicyclic succinimides derived from trifluoromethylmaleic anhydride were synthesized using cyclopentadiene or 2,3-dimethylbutadiene and (het)arylamines. The biological activity of these compounds was evaluated using prediction methods and experimental studies. This series of new trifluoromethyl succinimides (3a,b and 6a-c) were tested by the National Cancer Institute (NCI, Bethesda, USA) by Program NCI-60 DTP Human Tumor Cell Line Screen at a single high dose (10(-5) M). Imides revealed activity on Leukemia cell lines (RPMI-8226 - myeloma cell line), Non-Small Cell Lung Cancer cell lines (A549/ATCC - lung carcinoma epithelial cells) and Renal cancer cell lines (A498 and SN12C).
Authors:
Elena L Luzina; Anatoliy V Popov
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of fluorine chemistry     Volume:  168     ISSN:  0022-1139     ISO Abbreviation:  J Fluor Chem     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-11-17     Completed Date:  -     Revised Date:  2014-11-18    
Medline Journal Info:
Nlm Unique ID:  0373322     Medline TA:  J Fluor Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  121-127     Citation Subset:  -    
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