| Synthesis and anticancer activity of 5,6,8,13-tetrahydro-7H-naphtho[2,3-a][3]-benzazepine-8,13-diones. | |
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MedLine Citation:
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PMID: 22644844 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A series of naphthoquinones fused benzazepines, 5,6,8,13-tetrahydro-7H-naphtho[2,3-a][3]-benzazepine-8,13-diones, were synthesized and evaluated for their anticancer activity against four cell lines; human breast carcinoma cell line, human cervix carcinoma cell line, human hepatocellular carcinoma cell line and human keratinocyte cell line. The results showed that 5,6,8,13-tetrahydro-2,3,4,9-tetramethoxy-7H-naphtho[2,3-a][3]benzazepine-8,13-dione 4g and 5,6,8,13-tetrahydro-2,3,9-trimethoxy-7H-naphtho[2,3-a][3]benzazepine-8,13-dione 4h have significant cytotoxicity against a hepatocellular carcinoma cell line with IC(50) = 3.5 μg/mL and 3.0 μg/mL, respectively. |
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Authors:
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Weerachai Phutdhawong; Gedsirin Eksinitkun; Wanwikar Ruensumran; Thongchai Taechowisan; Waya S Phutdhawong |
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Publication Detail:
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Type: Journal Article Date: 2012-05-29 |
Journal Detail:
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Title: Archives of pharmacal research Volume: 35 ISSN: 0253-6269 ISO Abbreviation: Arch. Pharm. Res. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000036 Medline TA: Arch Pharm Res Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 769-77 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Faculty of Liberal Arts and Science, Kasetsart University, Kampang Saen campus, Nakhon Pathom, 73140, Thailand. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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