Document Detail


Synthesis and anticancer activity of 5,6,8,13-tetrahydro-7H-naphtho[2,3-a][3]-benzazepine-8,13-diones.
MedLine Citation:
PMID:  22644844     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A series of naphthoquinones fused benzazepines, 5,6,8,13-tetrahydro-7H-naphtho[2,3-a][3]-benzazepine-8,13-diones, were synthesized and evaluated for their anticancer activity against four cell lines; human breast carcinoma cell line, human cervix carcinoma cell line, human hepatocellular carcinoma cell line and human keratinocyte cell line. The results showed that 5,6,8,13-tetrahydro-2,3,4,9-tetramethoxy-7H-naphtho[2,3-a][3]benzazepine-8,13-dione 4g and 5,6,8,13-tetrahydro-2,3,9-trimethoxy-7H-naphtho[2,3-a][3]benzazepine-8,13-dione 4h have significant cytotoxicity against a hepatocellular carcinoma cell line with IC(50) = 3.5 μg/mL and 3.0 μg/mL, respectively.
Authors:
Weerachai Phutdhawong; Gedsirin Eksinitkun; Wanwikar Ruensumran; Thongchai Taechowisan; Waya S Phutdhawong
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Publication Detail:
Type:  Journal Article     Date:  2012-05-29
Journal Detail:
Title:  Archives of pharmacal research     Volume:  35     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  769-77     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Faculty of Liberal Arts and Science, Kasetsart University, Kampang Saen campus, Nakhon Pathom, 73140, Thailand.
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