| Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents. | |
| | |
MedLine Citation:
|
PMID: 22136907 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
A series of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxin congeners have been synthesized. All the twenty nine compounds were evaluated for anticancer activity against five human cancer cell lines (A-549, A375, MCF-7, HT-29 and ACHN). Some of the synthesized compounds showed good anticancer activity that is comparable to etoposide. The IC(50) of compounds 17a and 17f is 2.7 and 2.1 μM respectively against A-549 cancer cell line. Flow cytometric analysis showed that these two compounds arrested the cell cycle in the G2/M phase leading to caspase-3 dependent apoptotic cell death. Further, Hoechst 33258 staining and DNA fragmentation assay also suggested that 17a and 17f induced cell death by apoptosis. |
| | |
Authors:
|
Ahmed Kamal; Adla Mallareddy; Paidakula Suresh; V Lakshma Nayak; Rajesh V C R N C Shetti; N Sankara Rao; Jaki R Tamboli; Thokhir B Shaik; M V P S Vishnuvardhan; S Ramakrishna |
Related Documents
:
|
21637587 - Micronuclei induced by reverse transcriptase inhibitors in mononucleated and binucleate... 21945047 - Paraptosis-like cell death induced by yessotoxin. 22206747 - Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death i... 21895867 - Membrane sialidase neu3 is highly expressed in human melanoma cells promoting cell grow... 18640837 - Novel anticancer agents, kayeassamins a and b from the flower of kayea assamica of myan... 21305687 - C. elegans meg-1 and meg-2 differentially interact with nanos family members to either ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-20 |
Journal Detail:
|
Title: European journal of medicinal chemistry Volume: - ISSN: 1768-3254 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0420510 Medline TA: Eur J Med Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Masson SAS. All rights reserved. |
Affiliation:
|
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India; Catalytic Chemistry Chair, Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: New N-methylpiperazinyl derivatives of bicyclic antiprotozoal compounds.
Next Document: The two types of auto-immune pancreatitis.