Document Detail


Synthesis and antibacterial evaluation of typharin analog: 6,8-dihydroxy-7-methyl-3-styryl-3,4-dihydroisocoumarin.
MedLine Citation:
PMID:  23323839     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Synthesis of the 6-hydroxy-7-methyl analog of typharin (8-dihydroxy-3-styryl-3,4-dihydroisocoumarin) isolated from the rhizomes of Typha capensis has been described. Direct condensation of 3,5-dimethoxy-4-methylhomophthalic acid (1) with cinnamoyl chloride at elevated temperature under inert conditions afforded 6,8-dihydroxy-7-methyl-3-styrylisocoumarin (2). Hydrolysis of isocoumarin to keto acid (3) followed by reduction and cyclodehydration of hydroxy acid analog (4) afforded ( ± )-6,8-dimethoxy-3-(4-methoxyphenyl)-3,4-dihydroisocoumarin (5). Demethylation of the latter using anhydrous aluminum chloride/ethane thiol furnished the title isocoumarin (6). Compounds (1-6) were screened for in vitro antibacterial activity against a representative panel of Gram-positive and Gram-negative bacteria using levofloxacin as the reference drug.
Authors:
Aamer Saeed; Hummera Rafique; Zaman Ashraf
Related Documents :
24552719 - Recovery of volatile fatty acids (vfa) from complex waste effluents using membranes.
24026929 - Microbial communities and chemical changes during fermentation of sugary brazilian kefir.
23573029 - Phytic acid and raffinose series oligosaccharides metabolism in developing chickpea seeds.
23586989 - Novel family members of cyp109 from sorangium cellulosum so ce56 exhibit characteristic...
23360289 - Quantitative fate of chlorogenic acid during enzymatic browning of potato juice.
18325549 - 13c-labelling patterns of green leaf volatiles indicating different dynamics of precurs...
7238559 - A model for the generation of spontaneous yet predictable ventricular arrhythmias.
12862449 - Formation of low-symmetric 2d superlattices of gold nanoparticles through surface modif...
8978669 - Targeted mutagenesis of acyl-lipid desaturases in synechocystis: evidence for the impor...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Journal of Asian natural products research     Volume:  -     ISSN:  1477-2213     ISO Abbreviation:  J Asian Nat Prod Res     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888334     Medline TA:  J Asian Nat Prod Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a Department of Chemistry , Quaid-I-Azam University , 45320 , Islamabad , Pakistan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Obesity and impaired cognitive functioning in the elderly: a population-based cross-sectional study ...
Next Document:  Maternal Parenting Behaviors and Adolescent Depression: The Mediating Role of Rumination.