| Synthesis and antibacterial activity of C(2)-symmetric binaphthyl scaffolded amino acid derivatives. | |
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MedLine Citation:
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PMID: 21757269 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The synthesis of eleven novel antibacterial agents is reported. The structures are based on a C(2)-symmetric binaphthyl scaffold which holds two identical chains consisting of a short linker, a basic amino acid and a small hydrophobic side chain. Antibacterial activity is revealed for a number of derivatives down to an MIC of 2 μg/mL (2 μM) against Staphylococcus aureus - comparable to vancomycin, and an MIC of 31 μg/mL (31 μM) against some vancomycin-resistant enterococcal strains. |
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Authors:
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Mark Robertson; John B Bremner; Jonathan Coates; John Deadman; Paul A Keller; Stephen G Pyne; Kittiya Somphol; David I Rhodes |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-25 |
Journal Detail:
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Title: European journal of medicinal chemistry Volume: - ISSN: 1768-3254 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-7-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0420510 Medline TA: Eur J Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Crown Copyright © 2011. Published by Elsevier Masson SAS. All rights reserved. |
Affiliation:
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School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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