Document Detail


Synthesis and antibacterial activity of C(2)-symmetric binaphthyl scaffolded amino acid derivatives.
MedLine Citation:
PMID:  21757269     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The synthesis of eleven novel antibacterial agents is reported. The structures are based on a C(2)-symmetric binaphthyl scaffold which holds two identical chains consisting of a short linker, a basic amino acid and a small hydrophobic side chain. Antibacterial activity is revealed for a number of derivatives down to an MIC of 2 μg/mL (2 μM) against Staphylococcus aureus - comparable to vancomycin, and an MIC of 31 μg/mL (31 μM) against some vancomycin-resistant enterococcal strains.
Authors:
Mark Robertson; John B Bremner; Jonathan Coates; John Deadman; Paul A Keller; Stephen G Pyne; Kittiya Somphol; David I Rhodes
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-25
Journal Detail:
Title:  European journal of medicinal chemistry     Volume:  -     ISSN:  1768-3254     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-7-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0420510     Medline TA:  Eur J Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Crown Copyright © 2011. Published by Elsevier Masson SAS. All rights reserved.
Affiliation:
School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
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