Document Detail


Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives.
MedLine Citation:
PMID:  20488590     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of pyrazine-2-carboxylic acid hydrazide derivatives were synthesized and screened for their activity against Mycobacterium tuberculosis. The results show that pyrazine-2-carboxylic acid hydrazide-hydrazone derivatives 3a-l were less active than pyrazinamide. In contrast, the N(4)-ethyl-N(1)-pyrazinoyl-thiosemicarbazide 4 showed the highest activity against M. tuberculosis H(37)Rv (IC(90) = 16.87 microg/mL). Details of the structure-activity and structure-cytotoxicity relationships are discussed.
Authors:
Mohamed Abdel-Aziz; Hamdy M Abdel-Rahman
Publication Detail:
Type:  Journal Article     Date:  2010-04-28
Journal Detail:
Title:  European journal of medicinal chemistry     Volume:  45     ISSN:  1768-3254     ISO Abbreviation:  Eur J Med Chem     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0420510     Medline TA:  Eur J Med Chem     Country:  France    
Other Details:
Languages:  eng     Pagination:  3384-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
Affiliation:
Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519-Minia, Egypt. abulnil@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / chemical synthesis*,  chemistry,  pharmacology*
Cercopithecus aethiops
Hydrazines / chemical synthesis*,  chemistry,  pharmacology*
Mycobacterium tuberculosis / drug effects
Pyrazines / chemical synthesis*,  chemistry,  pharmacology*
Structure-Activity Relationship
Vero Cells
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Hydrazines; 0/Pyrazines; 0/pyrazine-2-carboxylic acid hydrazide; 302-01-2/hydrazine

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