| Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives. | |
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MedLine Citation:
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PMID: 21680063 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A number of 7-hydroxycoumarins have been synthesised by Pechmann cyclisation using differently substituted resorcinols employing perchloric acid as the condensing agent. All the compounds have been characterised by analytical and spectroscopic methods. The anti-inflammatory properties were tested with LPS-induced inflammation in J774 macrophages. Expression of iNOS and COX-2 was determined by Western blot, NO by nitrite assay and IL-6 by ELISA analyses. Fifteen of the tested 7-hydroxycoumarins also inhibited IL-6 production but none of them had any major inhibitory effect on COX-2 expression. |
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Authors:
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Juri M Timonen; Riina M Nieminen; Outi Sareila; Antonis Goulas; Lauri J Moilanen; Matti Haukka; Pirjo Vainiotalo; Eeva Moilanen; Paula H Aulaskari |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-30 |
Journal Detail:
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Title: European journal of medicinal chemistry Volume: - ISSN: 1768-3254 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-6-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0420510 Medline TA: Eur J Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Department of Chemistry, University of Eastern Finland, Joensuu Campus, P.O. Box 111, FIN-80101 Joensuu, Finland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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