| Synthesis, anti-bacterial, anti-asthmatic and anti-diabetic activities of novel N-substituted-2-(4-phenylethynyl-phenyl)-1H-benzimidazoles and N-substituted 2[4-(4,4-dimethyl-thiochroman-6-yl-ethynyl)-phenyl)-1H-benzimidazoles. | |
| | |
MedLine Citation:
|
PMID: 17825955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Synthesis of a series of novel and functionalized benzimidazole derivatives by the condensation of OPDA with 4-bromobenzoic acid and subsequent reactions of the product obtained with phenylacetylene and 6-ethynyl-4,4-dimethylthiochroman utilising Sonogashira coupling has been reported. The Sonogashira coupling products were then alkylated at the benzimidazole -NH with different electrophilic reagents leading to functionalized derivatives. All the compounds synthesized were screened for their potential anti-bacterial, anti-asthmatic and anti-diabetic properties, which exhibited moderate activities in screening studies in vitro. |
| | |
Authors:
|
Ramanatham Vinodkumar; Sanjay Dashrath Vaidya; Bobba Venkata Siva Kumar; Umesh Nanasaheb Bhise; Shekhar Bhaskar Bhirud; Uday Chandrakant Mashelkar |
Related Documents
:
|
19757815 - Synthesis, biological evaluation, and structure-activity relationships for 5-[(e)-2-ary... 22308405 - Leghemoglobin green derivatives with nitrated hemes evidence production of highly react... 11227995 - Synthesis and anti-rhinovirus activity of 2-styrylchromones. 20573425 - Design, synthesis and anti-ulcerogenic effect of some of furo-salicylic acid derivative... 20468025 - Electrochemical functionalization of 1,3-diisopropylbenzene. 21472295 - Antioxidant activity of fish sauces including puffer (lagocephalus wheeleri) fish sauce... |
Publication Detail:
|
Type: Journal Article Date: 2007-07-10 |
Journal Detail:
|
Title: European journal of medicinal chemistry Volume: 43 ISSN: 0223-5234 ISO Abbreviation: Eur J Med Chem Publication Date: 2008 May |
Date Detail:
|
Created Date: 2008-05-09 Completed Date: 2008-07-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0420510 Medline TA: Eur J Med Chem Country: France |
Other Details:
|
Languages: eng Pagination: 986-95 Citation Subset: IM |
Affiliation:
|
Glenmark Research Center, Plot No. A-607, T.T.C. Industrial Area, M.I.D.C. Mahape, Navi Mumbai 400 709, India. rvinodk@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alkynes
/
chemical synthesis*,
chemistry,
pharmacology Anti-Asthmatic Agents / chemical synthesis*, chemistry, pharmacology Anti-Bacterial Agents / chemical synthesis*, chemistry, pharmacology Antigens, CD26 / antagonists & inhibitors Benzimidazoles / chemical synthesis*, chemistry, pharmacology Cyclic Nucleotide Phosphodiesterases, Type 4 / antagonists & inhibitors Heterocyclic Compounds, 2-Ring / chemical synthesis*, chemistry, pharmacology Humans Hypoglycemic Agents / chemical synthesis*, chemistry, pharmacology Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
|
0/Alkynes; 0/Anti-Asthmatic Agents; 0/Anti-Bacterial Agents; 0/Benzimidazoles; 0/Heterocyclic Compounds, 2-Ring; 0/Hypoglycemic Agents; EC 3.1.3.48/Protein Tyrosine Phosphatase, Non-Receptor Type 1; EC 3.1.4.17/Cyclic Nucleotide Phosphodiesterases, Type 4; EC 3.4.14.5/Antigens, CD26 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: CoMFA and docking studies on triazolopyridine oxazole derivatives as p38 MAP kinase inhibitors.
Next Document: Challenges and promises for nurse education curriculum development in Kosovo: results of an "acciden...