Document Detail

Synthesis of angiotensin I-converting enzyme (ACE)-inhibitory peptides and gamma-aminobutyric acid (GABA) during sourdough fermentation by selected lactic acid bacteria.
MedLine Citation:
PMID:  18627167     Owner:  NLM     Status:  MEDLINE    
This article aimed at investigating the synthesis of angiotensin I-converting enzyme (ACE)-inhibitory peptides and gamma-aminobutyric acid (GABA) during sourdough fermentation of white wheat, wholemeal wheat, and rye flours. Sourdough lactic acid bacteria, selected previously for proteinase and peptidase activities toward wheat proteins or for the capacity of synthesizing GABA, were used. The highest ACE-inhibitory activity was found by fermenting flour under semiliquid conditions (dough yield 330) and, especially, by using wholemeal wheat flour. Fourteen peptides, not previously reported as ACE-inhibitory, were identified from the water/salt-soluble extract of wholemeal wheat sourdough (IC 50 0.19-0.54 mg/mL). The major part of the identified peptides contained the well-known antihypertensive epitope VAP. The synthesis of GABA increased when the dough yield was decreased to 160. The highest synthesis of GABA (258.71 mg/kg) was found in wholemeal wheat sourdough.
C G Rizzello; A Cassone; R Di Cagno; M Gobbetti
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Publication Detail:
Type:  Journal Article     Date:  2008-07-16
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  56     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-20     Completed Date:  2008-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6936-43     Citation Subset:  IM    
Department of Plant Protection and Applied Microbiology, University of Bari, 70126 Bari, Italy.
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MeSH Terms
Amino Acid Sequence
Angiotensin-Converting Enzyme Inhibitors / metabolism*,  pharmacology
Bread / analysis*
Chromatography, High Pressure Liquid
Lactobacillus / metabolism*
Molecular Sequence Data
Peptide Biosynthesis*
Peptides / chemistry,  isolation & purification,  pharmacology
gamma-Aminobutyric Acid / analysis,  biosynthesis*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Peptides; 56-12-2/gamma-Aminobutyric Acid

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