| Synthesis, analytical characterization and use of octakis(2,3-di-O-methyl-6-O-sulfo)-gamma-cyclodextrin, a novel, single-isomer, chiral resolving agent in low-pH background electrolytes. | |
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MedLine Citation:
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PMID: 12569527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The third member of the family of single-isomer, sulfated gamma-cyclodextrins, the sodium salt of octakis(2,3-di-O-methyl-6-O-sulfo)-gamma-cyclodextrin has been synthesized, analytically characterized and used for the capillary electrophoretic separation of the enantiomers of nonionic, weak acid and weak base analytes in low-pH aqueous background electrolytes. Though octakis(2,3-di-O-methyl-6-O-sulfo)-gamma-cyclodextrin complexes less strongly with many of the analytes tested than the other members of the single-isomer, 6-O-sulfo gamma-cyclodextrin family, such as octa(6-O-sulfo)-gamma-cyclodextrin and octakis(2,3-di-O-acetyl-6-O-sulfo)-gamma-cyclodextrin, it offers excellent separation selectivities, often complementary to those of both the single-isomer, 6-O-sulfo beta-cyclodextrins and 6-O-sulfo gamma-cyclodextrins. Rapid, efficient enantiomer separations were observed for a large number of structurally diverse analytes in acidic aqueous background electrolytes. |
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Authors:
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M Brent Busby; Peniel Lim; Gyula Vigh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Electrophoresis Volume: 24 ISSN: 0173-0835 ISO Abbreviation: Electrophoresis Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-02-05 Completed Date: 2003-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8204476 Medline TA: Electrophoresis Country: Germany |
Other Details:
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Languages: eng Pagination: 351-62 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Texas A & M University, College Station, TX 77842, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cyclodextrins
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chemical synthesis*,
chemistry Electrolytes Electrophoresis, Capillary / methods* Hydrogen-Ion Concentration Indicators and Reagents Organic Chemicals / isolation & purification Stereoisomerism gamma-Cyclodextrins* |
| Chemical | |
Reg. No./Substance:
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0/Cyclodextrins; 0/Electrolytes; 0/Indicators and Reagents; 0/Organic Chemicals; 0/gamma-Cyclodextrins; 0/octakis(2,3-dimethyl-6-O-sulfo)-gamma-cyclodextrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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