| Synthesis, analgesic and anti-inflammatory activities of some 1-acyl/aracyl-5-aminopyrazole derivatives. | |
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MedLine Citation:
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PMID: 8955869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of 1-acyl/aracyl-3, 4-disubstituted-5-aminopyrazoles (IV) were synthesized by the reaction of 1-acyl/aracylhydrazines (I) with an appropriately substituted ketenedithioacetal (II/III). Compounds IV were tested for their analgesic activity by rat caudal immersion test and anti-inflammatory activity by carrageenin induced edema in rat paw test. 1-Benzoyl-3-mercapto-4-carboxamido-5-aminopyrazole (IVk) proved to be the most active compound of the series in both tests. |
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Authors:
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A K Gadad; B S Kittur; S G Kapsi; C S Mahajanshetti; S B Rajur |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 46 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-03-17 Completed Date: 1997-03-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY |
Other Details:
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Languages: eng Pagination: 1082-5 Citation Subset: IM |
Affiliation:
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Department of Medicinal Chemistry, College of Pharmacy, J. N. Medical College, Belgaum, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Non-Narcotic
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chemical synthesis*,
pharmacology,
toxicity Animals Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*, pharmacology, toxicity Carrageenan Dose-Response Relationship, Drug Edema / chemically induced, prevention & control Female Male Mice Pain Measurement / drug effects Pyrazoles / chemical synthesis*, pharmacology, toxicity Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Non-Narcotic; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Pyrazoles; 9000-07-1/Carrageenan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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