Document Detail


Synthesis, analgesic and anti-inflammatory activities of some 1-acyl/aracyl-5-aminopyrazole derivatives.
MedLine Citation:
PMID:  8955869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of 1-acyl/aracyl-3, 4-disubstituted-5-aminopyrazoles (IV) were synthesized by the reaction of 1-acyl/aracylhydrazines (I) with an appropriately substituted ketenedithioacetal (II/III). Compounds IV were tested for their analgesic activity by rat caudal immersion test and anti-inflammatory activity by carrageenin induced edema in rat paw test. 1-Benzoyl-3-mercapto-4-carboxamido-5-aminopyrazole (IVk) proved to be the most active compound of the series in both tests.
Authors:
A K Gadad; B S Kittur; S G Kapsi; C S Mahajanshetti; S B Rajur
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  46     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-17     Completed Date:  1997-03-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1082-5     Citation Subset:  IM    
Affiliation:
Department of Medicinal Chemistry, College of Pharmacy, J. N. Medical College, Belgaum, India.
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MeSH Terms
Descriptor/Qualifier:
Analgesics, Non-Narcotic / chemical synthesis*,  pharmacology,  toxicity
Animals
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*,  pharmacology,  toxicity
Carrageenan
Dose-Response Relationship, Drug
Edema / chemically induced,  prevention & control
Female
Male
Mice
Pain Measurement / drug effects
Pyrazoles / chemical synthesis*,  pharmacology,  toxicity
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Pyrazoles; 9000-07-1/Carrageenan

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