| Synthesis, analgesic and anti inflammatory activities of some new fenamate analogues. | |
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MedLine Citation:
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PMID: 18972876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of fenamate quinazolinyl analogues, viz acids 6a-d, esters 6e-h, carbohydrazides 7a-d, arylidenes 8a-d, oxadiazol-2-ones 13a-d and oxadiazol-2-thiones 14a-d, have been prepared and screened for their analgesic (acetic acid-induced writhing), anti-inflammatory (carrageenan-induced rat paw edema) activities as well as their ulcerogenic effects. All the final compounds except 7a-d and 8a-d showed good dual activities. Compounds 6a, 6b, 6e, 6f, 13a and 14a showed activities comparable to that of mefenamic acid (CAS 61-68-7) in the acetic acid-induced writhing model as well as in the carrageenan-induced rat paw edema test at a dose level of 100 mg/ kg.Compounds 6a and 6b were highly ulcerogenic, while compounds 6e, 6f, 13a and 14a exhibited the lowest ulcerogenic effects. |
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Authors:
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Ahmed M Alafeefy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 58 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 2008 |
Date Detail:
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Created Date: 2008-10-31 Completed Date: 2008-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: Germany |
Other Details:
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Languages: eng Pagination: 457-63 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. aalafeefy@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acid
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diagnostic use Analgesics, Non-Narcotic / chemical synthesis*, pharmacology*, toxicity Animals Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*, pharmacology* Chemistry, Physical Edema / chemically induced, prevention & control Female Fenamates / chemical synthesis*, pharmacology*, toxicity Indicators and Reagents Magnetic Resonance Spectroscopy Male Mice Pain Measurement / drug effects Rats Spectrophotometry, Infrared Stomach Ulcer / chemically induced, pathology |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Non-Narcotic; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Fenamates; 0/Indicators and Reagents; 64-19-7/Acetic Acid |
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