| Synthesis of alkylaminoalkylamides of substituted 2-aminopyrroles as potential local anesthetic and antiarrhythmic agents I: alpha-Amines. | |
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MedLine Citation:
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PMID: 7205214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthesis, local anesthetic and antiarrhythmic properties, and CNS toxicity of 19 2-(2-alkylaminoalkylamido)pyrroles are described. Most of the compounds exhibited local anesthetic activity by the guinea pig wheal test, and four showed activity comparable to or greater than that of lidocaine. Most compounds also exhibited antiarrhythmic activity; five compounds had activity comparable to that of lidocaine, and one was more potent. All compounds exhibiting antiarrhythmic activity also were toxic to the central nervous system. |
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Authors:
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J W Sowell; A J Block; M E Derrick; J J Freeman; J W Kosh; R J Mattson; P F Mubarak; P A Tenthorey |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 70 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1981 Feb |
Date Detail:
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Created Date: 1981-05-28 Completed Date: 1981-05-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 135-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amides
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chemical synthesis,
pharmacology Anesthetics, Local / chemical synthesis* Animals Anti-Arrhythmia Agents / chemical synthesis* Chemical Phenomena Chemistry Guinea Pigs Heart Rate / drug effects Pyrroles / chemical synthesis*, pharmacology Skin Tests |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Anesthetics, Local; 0/Anti-Arrhythmia Agents; 0/Pyrroles |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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