| Synthesis and aggregation properties of a novel enzymatically resistant nucleoamino acid. | |
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MedLine Citation:
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PMID: 22252739 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this work, we describe the synthesis, evaluation of some biological properties, such as DNA- and RNA-binding ability and in sero stability, as well as the supramolecular assembly of a novel nucleoamino acid based on L: -spinacine. More particularly, a thymine-containing L: -spinacine derivative was synthesized in liquid phase by a simple peptide-coupling procedure. Subsequently, nucleic acid and Cu(2+)-binding ability, as well as self-assembly properties of the novel nucleoamino acid, were investigated by spectroscopy (CD and UV) and laser light scattering which furnished interesting information on the assembly of supramolecular networks based on the peptidyl nucleoside analog. Finally, nucleoamino acid enzymatic stability was studied and a half life of about 7 days was found in the presence of fresh human serum. |
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Authors:
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Giovanni N Roviello; Anna Mottola; Domenica Musumeci; Enrico M Bucci; Carlo Pedone |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
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Title: Amino acids Volume: - ISSN: 1438-2199 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200312 Medline TA: Amino Acids Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134, Naples, Italy, giovanni.roviello@cnr.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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