| Synthesis of zwitterionic salts of pyridinium-Meldrum acid and barbiturate through unique four-component reactions. | |
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MedLine Citation:
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PMID: 20092329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An efficient synthetic procedure for the preparation of the unusual charge-separated pyridinium-Meldrum acid and N,N-dimethylbarbiturate acid zwitterionic salts was developed though a unique one-pot four-component reaction involving pyridine, aromatic aldehyde, Meldrum acid or N,N-dimethylbarbituric acid, and p-nitrobenzyl bromide in acetonitrile. By varying combinations of four components involving nitrogen-containing heterocycles, we conveniently established reactive alpha-halomethylene compounds, aldehydes and beta-dicarbonyl compounds a library of zwitterionic salts. |
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Authors:
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Qi-Fang Wang; Li Hui; Hong Hou; Chao-Guo Yan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of combinatorial chemistry Volume: 12 ISSN: 1520-4774 ISO Abbreviation: J Comb Chem Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-07-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886263 Medline TA: J Comb Chem Country: United States |
Other Details:
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Languages: eng Pagination: 260-5 Citation Subset: IM |
Affiliation:
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College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Barbiturates
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chemistry* Dioxanes / chemistry* Heterocyclic Compounds / chemistry Models, Molecular Pyridinium Compounds / chemistry* Salts / chemical synthesis* |
| Chemical | |
Reg. No./Substance:
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0/Barbiturates; 0/Dioxanes; 0/Heterocyclic Compounds; 0/Pyridinium Compounds; 0/Salts; 2033-24-1/Meldrum's acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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