| Synthesis and Transformations of di-endo-3-Aminobicyclo-[2.2.2]oct-5-ene-2-carboxylic Acid Derivatives. | |
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MedLine Citation:
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PMID: 21900870 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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all-endo-3-amino-5-hydroxybicyclo[2.2.2]octane-2-carboxylic acid (13) and all-endo-5-amino-6-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol (10) were prepared via dihydro-1,3-oxazine or g-lactone intermediates by the stereoselective functionalization of an N-protected derivative of endo-3-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acid (2). Ring closure of b-amino ester 4 resulted in tricyclic pyrimidinones 15 and 16. The structures, stereochemistry and relative configurations of the synthesized compounds were determined by IR and NMR. |
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Authors:
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Márta Palkó; Pál Sohár; Ferenc Fülöp |
Publication Detail:
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Type: Journal Article Date: 2011-09-07 |
Journal Detail:
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Title: Molecules (Basel, Switzerland) Volume: 16 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2011 |
Date Detail:
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Created Date: 2011-09-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
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Languages: eng Pagination: 7691-705 Citation Subset: IM |
Affiliation:
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Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös utca 6, Hungary. fulop@pharm.u-szeged.hu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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