Document Detail


Synthesis and Studies on the Anticonvulsant Activity of 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine Derivatives.
MedLine Citation:
PMID:  22782505     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this study, a series of new 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine derivatives was synthesized and their anticonvulsant activity and neurotoxicity was evaluated with the maximal electroshock and rotarod tests, respectively. The most promising compounds, 3p (5-(4-chlorophenoxy)-[1,2,4]triazolo[4,3-a]pyridine) and 3r (5-(4-bromophenoxy)-[1,2,4]triazolo[4,3-a]pyridine), showed a median effective dose of 13.2 and 15.8 mg/kg and had a protective index value of 4.8 and 6.9, respectively. For exploring the putative mechanism of action, compounds 3n, 3p and 3r were tested in chemically induced models.
Authors:
L-P Guan; R-P Zhang; Y Sun; Y Chang; X Sui
Related Documents :
23952285 - Synthesis of 2-alkenyl- and 2-alkynyl-benzo[b]phospholes by using palladium-catalyzed c...
10591055 - The behaviour of aryl pyrrolines with monoamine oxidase.
18032055 - Synthesis and structure-activity relationships of 16-ene-22-thia-1alpha,25-dihydroxy-26...
22953715 - An efficient synthesis of bridged heterocycles from an ir(i) bis-amination/ring-closing...
21409265 - Total synthesis of novel d-ring-modified triptolide analogues: structure-cytotoxic acti...
23113545 - Cecl(3)·7h(2)o catalyzed c-c and c-n bond-forming cascade cyclization with subsequent ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-10
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  -     ISSN:  0004-4172     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
School of Food, Drug & Medicine Zhejiang Ocean University, Zhejiang, Zhoushan, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Loss of expression of the differentially expressed in adenocarcinoma of the lung (DAL-1) protein is ...
Next Document:  Pharmacokinetics of salsalate and salicylic acid in normal and diabetic rats.