| Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agents. | |
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MedLine Citation:
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PMID: 20005100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sulfonyl amidines (1) and phosphoryl amidines (2), which were efficiently synthesized via a Cu-catalyzed one pot reaction, showed potent anti-bone resorptive activity in vitro. Structure activity relationship studies led to the identification of numerous osteoclast differentiation inhibitors. |
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Authors:
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Myung Yun Lee; Myung Hee Kim; Jinho Kim; Seok Hwan Kim; Bum Tae Kim; In Howa Jeong; Sukbok Chang; Seong Hwan Kim; Sung-Youn Chang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-26 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 20 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 541-5 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Chemistry and Medical Chemistry, Yonsei University, Wonju 220-710, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid Phosphatase
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metabolism Amidines / chemical synthesis*, chemistry, pharmacology Animals Catalysis Copper / chemistry Isoenzymes / metabolism Mice Osteoclasts / drug effects Phosphonic Acids / chemistry* Structure-Activity Relationship Sulfones / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Amidines; 0/Isoenzymes; 0/Phosphonic Acids; 0/Sulfones; 7440-50-8/Copper; EC 3.1.3.-/tartrate-resistant acid phosphatase; EC 3.1.3.2/Acid Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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