| Synthesis of (S)-1-(2',3'-dihydroxypropyl)-2-alkylthiouracils as new antiviral agents. | |
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MedLine Citation:
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PMID: 9675767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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2-Alkylthiouracils 1a-f have been prepared. Nucleoside coupling of 2 with sodium salt of 1a-f gave the corresponding dioxolane derivatives 3a-f which were treated with 80% acetic acid at reflux temperature to give (S)-1-(2',3'-dihydroxypropyl)-2-alkylthiouracil derivatives 4a-f. Treatment of 4d with 1 mol tosyl chloride gives the corresponding monotosylate 5. On the other hand, with 2 mol it gives the ditosylate 6. Treatment of 5 and/or 6 with sodium azide/dimethylformamide give 7 and 8 which could be reduced to the corresponding amino derivatives 9 and 10 by using triphenylphosphine/pyridine. |
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Authors:
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A A Rahman; M T Aal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Die Pharmazie Volume: 53 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-08-20 Completed Date: 1998-08-20 Revised Date: 2007-01-29 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: GERMANY |
Other Details:
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Languages: eng Pagination: 377-80 Citation Subset: IM; X |
Affiliation:
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Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-HIV Agents
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chemical synthesis*,
pharmacology Hepatitis B virus / drug effects, physiology Humans Magnetic Resonance Spectroscopy Thiouracil / analogs & derivatives, chemical synthesis*, pharmacology Virus Replication / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 141-90-2/Thiouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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