Document Detail

Synthesis of Rubrolide Analogues as New Inhibitors of the Photosynthetic Electron Transport Chain.
MedLine Citation:
PMID:  23025464     Owner:  NLM     Status:  Publisher    
Many natural products have been used as a model for the development of new drugs and agrochemicals. Following this strategy eleven rubrolide analogues, bearing electron withdrawing and donating groups at both benzene rings, were prepared starting from commercially available mucobromic acid. The ability of all compounds to inhibit the photosynthetic electron transport chain in chloroplast was investigated. The rubrolide analogs were effective in interfering with the light-driven ferricyanide reduction by isolated chloroplasts. The IC50 values of the most active derivatives are in fact only one order of magnitude higher than those of commercial herbicides sharing the same mode of action, as Diuron (0.27 µM). QSAR studies indicate that the most efficient compounds are those having higher ability to accept electron, either by a reduction process or by an electrophilic reaction mechanism. The results obtained suggest that the rubrolide analogues represent promising candidates for the development of new active principles targeting photosynthesis to be used as herbicides.
Luiz Claudio Almeida Barbosa; Celia Ra Maltha; Mateus R Lage; Rosimeire C Barcelos; Alice Dona; José W M Carneiro; Giuseppe Forlani
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-2
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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