| Synthesis, RNA selective hybridization and high nuclease resistance of an oligonucleotide containing novel bridged nucleic acid with cyclic urea structure. | |
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MedLine Citation:
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PMID: 20567794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel bridged nucleic acid bearing cyclic urea structure was successfully synthesized and introduced into oligonucleotide, displaying attractive characteristics of highly RNA selective hybridization ability and excellent resistance towards nuclease degradation. |
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Authors:
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Masaru Nishida; Takeshi Baba; Tetsuya Kodama; Aiko Yahara; Takeshi Imanishi; Satoshi Obika |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-22 |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: 46 ISSN: 1364-548X ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-15 Completed Date: 2010-10-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: England |
Other Details:
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Languages: eng Pagination: 5283-5 Citation Subset: IM |
Affiliation:
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Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Crotalus / metabolism* Cyclization Molecular Structure Nucleic Acid Hybridization Nucleic Acids / chemistry* Oligonucleotides / chemical synthesis* Phosphoric Diester Hydrolases / metabolism* RNA / chemistry* Urea / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids; 0/Oligonucleotides; 57-13-6/Urea; 63231-63-0/RNA; EC 3.1.4.-/Phosphoric Diester Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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