| Synthesis and photodynamic effect of new highly photostable decacationically armed [60]- and [70]fullerene decaiodide monoadducts to target pathogenic bacteria and cancer cells. | |
| | |
MedLine Citation:
|
PMID: 22512669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Novel water-soluble decacationically armed C(60) and C(70) decaiodide monoadducts, C(60)- and C(70)[>M(C(3)N(6)(+)C(3))(2)], were synthesized, characterized, and applied as photosensitizers and potential nano-PDT agents against pathogenic bacteria and cancer cells. A high number of cationic charges per fullerene cage and H-bonding moieties were designed for rapid binding to the anionic residues displayed on the outer parts of bacterial cell walls. In the presence of a high number of electron-donating iodide anions as parts of quaternary ammonium salts in the arm region, we found that C(70)[>M(C(3)N(6)(+)C(3))(2)] produced more HO(•) than C(60)[>M(C(3)N(6)(+)C(3))(2)], in addition to (1)O(2). This finding offers an explanation of the preferential killing of Gram-positive and Gram-negative bacteria by C(60)[>M(C(3)N(6)(+)C(3))(2)] and C(70)[>M(C(3)N(6)(+)C(3))(2)], respectively. The hypothesis is that (1)O(2) can diffuse more easily into porous cell walls of Gram-positive bacteria to reach sensitive sites, while the less permeable Gram-negative bacterial cell wall needs the more reactive HO(•) to cause real damage. |
| | |
Authors:
|
Min Wang; Liyi Huang; Sulbha K Sharma; Seaho Jeon; Sammaiah Thota; Felipe F Sperandio; Suhasini Nayka; Julie Chang; Michael R Hamblin; Long Y Chiang |
Related Documents
:
|
21315819 - Micrornas and the cell cycle. 21236489 - Effects of exogenous agmatine in human leukemia hmc-1 and hl-60 cells on proliferation,... 21432519 - Stimulation of hydrogen peroxide production by drinking water contaminants in hl-60 cel... 22624979 - Chlamydia co-opts the rod-shape determining proteins mreb and pbp2 for cell division. 21097889 - Pak1ip1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via... 12635719 - A revised economic analysis of restrictions on the use of cell phones while driving. 2246409 - Complete spontaneous regression of multiple basal cell carcinomas in the basal cell nev... 12011359 - Turgor regulation in osmotically stressed arabidopsis epidermal root cells. direct supp... 3109929 - The effect of recombinant human tumour necrosis factor on growth and macromolecular syn... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-04-26 |
Journal Detail:
|
Title: Journal of medicinal chemistry Volume: 55 ISSN: 1520-4804 ISO Abbreviation: J. Med. Chem. Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-05-10 Completed Date: 2012-09-12 Revised Date: 2013-05-13 |
Medline Journal Info:
|
Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: United States |
Other Details:
|
Languages: eng Pagination: 4274-85 Citation Subset: IM |
Affiliation:
|
Department of Chemistry, Institute of Nanoscience and Engineering Technology, University of Massachusetts, Lowell, Massachusetts 01854, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antineoplastic Agents
/
chemical synthesis,
chemistry,
pharmacology* Bacteria / drug effects* Drug Stability Fullerenes / chemistry, pharmacology* HeLa Cells Humans Iodides / chemical synthesis, chemistry, pharmacology* Magnetic Resonance Spectroscopy Photochemotherapy / methods* Photosensitizing Agents / chemical synthesis, chemistry, pharmacology* Quaternary Ammonium Compounds / chemical synthesis, chemistry, pharmacology* Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrophotometry, Ultraviolet |
| Grant Support | |
ID/Acronym/Agency:
|
1R01CA137108/CA/NCI NIH HHS; R01 CA137108/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 0/Fullerenes; 0/Iodides; 0/Photosensitizing Agents; 0/Quaternary Ammonium Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Radiative and Nonradiative Properties of Single Plasmonic Nanoparticles and Their Assemblies.
Next Document: The reassurance questionnaire: Comparison of the latent structure in university, community, and medi...