Document Detail

Synthesis of new polysialic acid derivatives.
MedLine Citation:
PMID:  20602419     Owner:  NLM     Status:  MEDLINE    
In this paper we report the first synthesis of novel polysialic acid derivatives which is initiated by treatment of polysialic acid with EDC-HCl to yield the inter-residual delta-lactone. Subsequent reaction with amines or hydrazine gives the corresponding polysialic acid amides and hydrazide. Alkylation of the tetrabutylammonium salt of polysialic acid yields polysialic acid esters. In contrast a variety of N-derivatives of polysialic acid can be prepared starting from deacetylated polysialic acid. The N-derivatives prepared in this communication can be used for the Cu-catalyzed as well as Cu-free "click" chemistry.
Yi Su; Cornelia Kasper; Andreas Kirschning; Gerald Dräger; Silke Berski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Macromolecular bioscience     Volume:  10     ISSN:  1616-5195     ISO Abbreviation:  Macromol Biosci     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135941     Medline TA:  Macromol Biosci     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1028-33     Citation Subset:  IM    
Institut für Organische Chemie, Gottfried Wilhelm Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany.
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MeSH Terms
Click Chemistry
Sialic Acids / chemical synthesis*
Reg. No./Substance:
0/Amides; 0/Esters; 0/Hydrazines; 0/Lactones; 0/Sialic Acids; 0/polysialic acid

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