| Synthesis of new polysialic acid derivatives. | |
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MedLine Citation:
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PMID: 20602419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this paper we report the first synthesis of novel polysialic acid derivatives which is initiated by treatment of polysialic acid with EDC-HCl to yield the inter-residual delta-lactone. Subsequent reaction with amines or hydrazine gives the corresponding polysialic acid amides and hydrazide. Alkylation of the tetrabutylammonium salt of polysialic acid yields polysialic acid esters. In contrast a variety of N-derivatives of polysialic acid can be prepared starting from deacetylated polysialic acid. The N-derivatives prepared in this communication can be used for the Cu-catalyzed as well as Cu-free "click" chemistry. |
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Authors:
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Yi Su; Cornelia Kasper; Andreas Kirschning; Gerald Dräger; Silke Berski |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Macromolecular bioscience Volume: 10 ISSN: 1616-5195 ISO Abbreviation: Macromol Biosci Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-12-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: Germany |
Other Details:
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Languages: eng Pagination: 1028-33 Citation Subset: IM |
Affiliation:
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Institut für Organische Chemie, Gottfried Wilhelm Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acylation Alkylation Amides Click Chemistry Esters Hydrazines Lactones Sialic Acids / chemical synthesis* |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Esters; 0/Hydrazines; 0/Lactones; 0/Sialic Acids; 0/polysialic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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