Document Detail


Synthesis of N(alpha)-Boc-N(epsilon)-tetrabenzyl-DTPA-L-lysine and N(alpha)-Fmoc-N(epsilon)-tetra-t-butyl-DTPA-L-lysine, building blocks for solid phase synthesis of DTPA-containing peptides.
MedLine Citation:
PMID:  12523643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two building blocks, Boc-Lys(Bn4-DTPA)-OH and Fmoc-Lys(Bu4(t)-DTPA)-OH have been synthesized via the acylation of the epsilon-amino group of N(alpha)-protected lysine, using suitably protected tetra-esters of diethylene triamine pentaacetic acid (DTPA), a ligand with wide application as a chelating agent for complexing metal tons to peptides.
Authors:
John S Davies; Loai Al-Jamri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of peptide science : an official publication of the European Peptide Society     Volume:  8     ISSN:  1075-2617     ISO Abbreviation:  J. Pept. Sci.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-13     Completed Date:  2003-06-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9506309     Medline TA:  J Pept Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  663-70     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK. j.s.davies@swansea.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Acylation
Amino Acids / chemistry
Chelating Agents / chemistry
Fluorenes / chemistry
Lysine / analogs & derivatives*,  chemistry
Pentetic Acid / analogs & derivatives*,  chemistry
Peptides / chemical synthesis*,  chemistry
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Chelating Agents; 0/Fluorenes; 0/N(alpha)-fluorenylmethyloxycarbonylamino acids; 0/Peptides; 56-87-1/Lysine; 67-43-6/Pentetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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