| Synthesis of N-[tris[2-[[N-(benzyloxy)amino]carbonyl]ethyl]methyl]succinamic acid, trisuccin. Hydroxamic acid derivatives as a new class of bifunctional chelating agents. | |
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MedLine Citation:
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PMID: 8324008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an effort to generate bifunctional chelating agents (BCAs) with improved labeling, conjugation, and biodistribution properties, the synthesis of trisuccin is reported. This new hydroxamate BCA, after synthesis and characterization, was used for conjugation and radiolabeling of monoclonal antibodies with 99mTc. This new class of synthetic BCAs may be useful in the radioimmunodiagnosis and radioimmunotherapy of cancer. |
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Authors:
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A Safavy; D J Buchsbaum; M B Khazaeli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bioconjugate chemistry Volume: 4 ISSN: 1043-1802 ISO Abbreviation: Bioconjug. Chem. Publication Date: 1993 May-Jun |
Date Detail:
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Created Date: 1993-08-09 Completed Date: 1993-08-09 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 9010319 Medline TA: Bioconjug Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 194-8 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, University of Alabama, Birmingham 35233. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal Chelating Agents / chemical synthesis*, chemistry Chromatography, Thin Layer Cross-Linking Reagents / chemical synthesis*, chemistry Hydroxamic Acids / chemical synthesis*, chemistry Immunotoxins / chemistry Isotope Labeling / methods Magnetic Resonance Spectroscopy Succinates / chemical synthesis*, chemistry Technetium / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Chelating Agents; 0/Cross-Linking Reagents; 0/Hydroxamic Acids; 0/Immunotoxins; 0/Succinates; 147219-26-9/trisuccin; 7440-26-8/Technetium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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