| Synthesis of N-epsilon-lithocholyl-L-lysine, a component of tissue-bound lithocholic acid, via lithocholyl-N-hydroxysuccinimide. | |
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MedLine Citation:
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PMID: 4079375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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N-epsilon-lithocholyl-l-lysine is a lithocholic acid modified lysine residue found in proteins from tissues. This paper describes the synthesis of this compound as well as that of the isomeric N-alpha-lithocholyl-l-lysine and the di-substituted N-alpha-epsilon-bis-lithocholyl-l-lysine. The procedure involves the initial coupling of lithocholyl-N-hydroxysuccinimide to the appropriate N-alpha- or N-epsilon-CBZ (carbobenzloxy) protected lysine derivative followed by hydrogenolysis with palladium black of the CBZ group using formic acid as the hydrogen donor. |
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Authors:
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P P Nair; G Kessie; N Turjman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of steroid biochemistry Volume: 23 ISSN: 0022-4731 ISO Abbreviation: J. Steroid Biochem. Publication Date: 1985 Nov |
Date Detail:
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Created Date: 1986-01-31 Completed Date: 1986-01-31 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 0260125 Medline TA: J Steroid Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 573-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, Thin Layer Lithocholic Acid / analogs & derivatives*, chemical synthesis Succinimides |
| Chemical | |
Reg. No./Substance:
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0/Succinimides; 104211-94-1/lithocholyl-N-hydroxysuccinimide; 434-13-9/Lithocholic Acid; 65236-49-9/N-epsilon-lithocholyllysine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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