| Synthesis of N-(2-hydroxypropyl)methacrylamide copolymers with antimicrobial activity. | |
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MedLine Citation:
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PMID: 6301566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Copolymers of N-(2-hydroxypropyl)methacrylamide which contained up to 20 mol % of p-nitrophenyl esters of N-methacryloylated oligopeptides, and of N-methacryloylaminophenoxyacetic acids (o-, m-, p-) have been prepared. The aminolyses of these polymers with tert. butylamine, ampicillin and 6-aminopenicillanic acid were kinetically characterized. Based on these results polymer bound ampicillin and polymer bound 6-aminopenicillanic acid were prepared. These preparations possessed antimicrobial activity; they inhibited the growth of Staphylococcus aureus 209 P. |
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Authors:
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M V Solovskij; K Ulbrich; J Kopecek |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomaterials Volume: 4 ISSN: 0142-9612 ISO Abbreviation: Biomaterials Publication Date: 1983 Jan |
Date Detail:
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Created Date: 1983-06-10 Completed Date: 1983-06-10 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 44-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrylates
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chemical synthesis* Ampicillin Anti-Bacterial Agents / chemical synthesis*, pharmacology Bacteria / drug effects Kinetics Methacrylates / chemical synthesis*, pharmacology Penicillanic Acid |
| Chemical | |
Reg. No./Substance:
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0/Acrylates; 0/Anti-Bacterial Agents; 0/Methacrylates; 551-16-6/aminopenicillanic acid; 69-53-4/Ampicillin; 87-53-6/Penicillanic Acid; 923-26-2/2-hydroxypropyl methacrylate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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