Document Detail


Synthesis of N-(2-hydroxypropyl)methacrylamide copolymers with antimicrobial activity.
MedLine Citation:
PMID:  6301566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Copolymers of N-(2-hydroxypropyl)methacrylamide which contained up to 20 mol % of p-nitrophenyl esters of N-methacryloylated oligopeptides, and of N-methacryloylaminophenoxyacetic acids (o-, m-, p-) have been prepared. The aminolyses of these polymers with tert. butylamine, ampicillin and 6-aminopenicillanic acid were kinetically characterized. Based on these results polymer bound ampicillin and polymer bound 6-aminopenicillanic acid were prepared. These preparations possessed antimicrobial activity; they inhibited the growth of Staphylococcus aureus 209 P.
Authors:
M V Solovskij; K Ulbrich; J Kopecek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomaterials     Volume:  4     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  44-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acrylates / chemical synthesis*
Ampicillin
Anti-Bacterial Agents / chemical synthesis*,  pharmacology
Bacteria / drug effects
Kinetics
Methacrylates / chemical synthesis*,  pharmacology
Penicillanic Acid
Chemical
Reg. No./Substance:
0/Acrylates; 0/Anti-Bacterial Agents; 0/Methacrylates; 551-16-6/aminopenicillanic acid; 69-53-4/Ampicillin; 87-53-6/Penicillanic Acid; 923-26-2/2-hydroxypropyl methacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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