| Synthesis of N-[2-(2,4-Difluorophenoxy)trifluoromethyl-3-pyridyl]sulfonamides and Their Inhibitory Activities against Secretory Phospholipase A(2). | |
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MedLine Citation:
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PMID: 21804258 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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N-[2-(2,4-Difluorophenoxy)trifluoromethyl-3-pyridyl]sulfonamide derivatives 3-6 were prepared by the reaction of 3-pyridylamines and sulfonyl chlorides. Inhibitory activities of these compounds toward secretory phospholipase A(2) (sPLA(2)) were examined and N-[2-(2,4-difluorophenoxy)-5-trifluoromethyl-3-pyridyl]-2-naphthalenesulfonamide (5c) was found to be the most potent against sPLA(2) with an IC(50) value of 90 µM. |
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Authors:
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Hitoshi Nakayama; Keiichi Ishihara; Satoshi Akiba; Jun'ichi Uenishi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 59 ISSN: 1347-5223 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-08-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 1069-72 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Chemistry, Kyoto Pharmaceutical University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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