| Synthesis and Identification of New 4-Arylidene Curcumin Analogues as Potential Anticancer Agents Targeting Nuclear Factor-κB Signaling Pathway. | |
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MedLine Citation:
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PMID: 21070043 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A series of curcumin analogues including new 4-arylidene curcumin analogues (4-arylidene-1,7-bisarylhepta-1,6-diene-3,5-diones) were synthesized. Cell growth inhibition assays revealed that most 4-arylidene curcumin analogues can effectively decrease the growth of a panel of lung cancer cells at submicromolar and low micromolar concentrations. High content analysis technology coupled with biochemical studies showed that this new class of 4-arylidene curcumin analogues exhibits significantly improved NF-κB inhibition activity over the parent compound curcumin, at least in part by inhibiting IκB phosphorylation and degradation via IKK blockage; selected 4-arylidene curcumin analogues also reduced the tumorigenic potential of cancer cells in a clonogenic assay. |
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Authors:
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Xu Qiu; Yuhong Du; Bin Lou; Yinglin Zuo; Weiyan Shao; Yingpeng Huo; Jianing Huang; Yanjun Yu; Binhua Zhou; Jun Du; Haian Fu; Xianzhang Bu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-11-11 |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: - ISSN: 1520-4804 ISO Abbreviation: - Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510275, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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