| Synthesis and Ex Vivo Autoradiographic Evaluation of Ethyl-β-D: -galactopyranosyl-(1,4')-2'-deoxy-2'-[(18)F]fluoro-β-D: -glucopyranoside-A Novel Radioligand for Lactose-Binding Protein: Implications for Early Detection of Pancreatic Carcinomas with PET. | |
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MedLine Citation:
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PMID: 20593279 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: Previous studies demonstrated that the lactose-binding protein (hepatocellular carcinoma-intestine-pancreas and pancreatitis-associated proteins (HIP/PAP)) is upregulated >130 times in peritumoral pancreatic tissue as compared to normal pancreatic tissue. Therefore, we developed a new radiolabeled ligand of HIP/PAP, the ethyl-β-D: -galactopyranosyl-(1,4')-2'-deoxy-2'-[(18)F]fluoro-β-D: -glucopyranoside (Et-[(18)F]FDL) for noninvasive imaging of pancreatic carcinoma using positron emission tomography and computerized tomography (PET/CT). METHODS: The novel precursor and radiolabeling methods for synthesis of Et-[(18)F]FDL produced no isomers; the average decay-corrected radiochemical yield was 68%, radiochemical purity >99%, and specific activity >74 GBq/µmol. The radioligand properties of Et-[(18)F]FDL were evaluated using an ex vivo autoradiography and immunohistochemistry in pancreatic tissue sections obtained from mice-bearing orthotopic pancreatic tumor xenografts. RESULTS AND DISCUSSION: Et-[(18)F]FDL binding to peritumoral pancreatic tissue sections strongly correlated with HIP/PAP expression (r = 0.81) and could be completely blocked by treatment with 1 mM lactose. CONCLUSION: These results suggest that Et-[(18)F]FDL is a promising agent which should be evaluated for detection of early pancreatic carcinomas by PET/CT imaging. |
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Authors:
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Yunming Ying; Pradip Ghosh; Liwei Guo; Ashutosh Pal; Uday Mukhapadhyay; Zhenghong Peng; Hsin Hsien Yeh; Susanna Bertolini; Leo Garcia Flores; Daniel Young; Andrei Volgin; Suren Soghomonyan; William Bornmann; Craig Logsdon; Mian M Alauddin; Juri G Gelovani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Volume: 13 ISSN: 1860-2002 ISO Abbreviation: Mol Imaging Biol Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125610 Medline TA: Mol Imaging Biol Country: United States |
Other Details:
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Languages: eng Pagination: 536-46 Citation Subset: IM |
Affiliation:
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Department of Experimental Diagnostic Imaging, Center for Advanced Biomedical Imaging Research (CABIR), The University of Texas MD Anderson Cancer Center, 1881 East Road, 3SCR2.3924, Houston, TX, 77030, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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