Document Detail

Synthesis and evaluation of novel 2-substituted-quinazolin-4(3H)-ones as potent analgesic and anti-inflammatory agents.
MedLine Citation:
PMID:  20108268     Owner:  NLM     Status:  MEDLINE    
A novel series of 2-substituted-quinazolin-4(3H)-ones were synthesized by reacting 3,5-disubstituted-anthranilic acid with acetic anhydride/benzoyl chloride, which were further reacted with different primary amines to obtain 2,6,8-substituted-quinazolin-4(3H)-ones 6a-f, 7, 8. All the synthesized compounds were characterized and screened for analgesic and anti-inflammatory activities. Compounds 6,8-dibromo-2-phenyl-3-(4'-carboxyl phenyl)quinazolin-4(3H)-one 7 and 6,8-dibromo-2-phenyl-3-(2'-phenylethanoic acid)quinazolin-4(3H)-one 8 displayed good analgesic and anti-inflammatory activity in comparison to the reference standards acetyl salicylic acid and indomethacin, respectively.
Bilal Ahmad Rather; Tilak Raj; Aravind Reddy; Mohan Paul S Ishar; Samitha Sivakumar; Perumal Paneerselvam
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archiv der Pharmazie     Volume:  343     ISSN:  1521-4184     ISO Abbreviation:  Arch. Pharm. (Weinheim)     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-26     Completed Date:  2010-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330167     Medline TA:  Arch Pharm (Weinheim)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  108-13     Citation Subset:  IM    
Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
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MeSH Terms
Analgesics / chemical synthesis,  pharmacology*
Anti-Inflammatory Agents / chemical synthesis,  chemistry,  pharmacology*
Aspirin / pharmacology
Disease Models, Animal
Indomethacin / pharmacology
Inflammation / drug therapy
Pain / drug therapy
Pain Measurement
Quinazolines / chemical synthesis,  pharmacology*
Structure-Activity Relationship
Reg. No./Substance:
0/Analgesics; 0/Anti-Inflammatory Agents; 0/Quinazolines; 50-78-2/Aspirin; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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