Document Detail


Synthesis and distribution of CARDS toxin during Mycoplasma pneumoniae infection in a murine model.
MedLine Citation:
PMID:  21957154     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mice were infected with Mycoplasma pneumoniae and monitored for the synthesis and distribution of the unique adenosine diphosphate-ribosylating and vacuolating Community Acquired Respiratory Distress Syndrome (CARDS) toxin in bronchiolar lavage fluid (BALF) and lung. We noted direct relationships between the concentration of CARDS toxin and numbers of mycoplasma genomes in BALF and the degree of histologic pulmonary inflammation. Immunostaining of lungs revealed extensive colonization by mycoplasmas, including the detection of CARDS toxin in the corresponding inflamed airways. Lung lesion scores were higher during the early stages of infection, decreased gradually by day 14 postinfection, and reached substantially lower values at day 35. Infected mouse immunoglobulin (Ig) M and IgG titers were positive for CARDS toxin as well as for the major adhesin P1 of M. pneumoniae. These data reinforce the proposed pathogenic role of CARDS toxin in M. pneumoniae-mediated pathologies.
Authors:
T R Kannan; Jacqueline J Coalson; Marianna Cagle; Oxana Musatovova; R Doug Hardy; Joel B Baseman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-09-28
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  204     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-14     Completed Date:  2011-12-14     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1596-604     Citation Subset:  AIM; IM    
Affiliation:
Department of Microbiology and Immunology, University of Texas Health Sciences Center at San Antonio, TX, USA.
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MeSH Terms
Descriptor/Qualifier:
Adhesins, Bacterial / metabolism
Animals
Antibodies, Bacterial / blood
Bacterial Proteins / metabolism*
Bacterial Toxins / metabolism*
Bronchoalveolar Lavage Fluid / chemistry,  microbiology
Disease Models, Animal
Female
Lung / chemistry,  microbiology
Mice
Mice, Inbred BALB C
Mycoplasma pneumoniae / immunology,  isolation & purification,  metabolism*,  pathogenicity
Pneumonia, Mycoplasma / blood,  microbiology*
Grant Support
ID/Acronym/Agency:
U19AI070412/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Adhesins, Bacterial; 0/Antibodies, Bacterial; 0/Bacterial Proteins; 0/Bacterial Toxins; 0/CARDS toxin, Mycoplasma pneumoniae; 0/adhesin, Mycoplasma pneumoniae
Comments/Corrections

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