Document Detail


Synthesis and DNA binding selectivity of pyrrole-amidine oligopeptides.
MedLine Citation:
PMID:  8494595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A class of DNA binding antibiotics endowed with antiviral and antitumor properties is reviewed. Starting from the original natural products, namely distamycin and netropsin, new compounds have been recently synthesized with the aim to obtain agents with specific affinity for defined DNA sequences and with different interaction mechanism (reversible or irreversible).
Authors:
F Arcamone
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Farmaco (Società chimica italiana : 1989)     Volume:  48     ISSN:  0014-827X     ISO Abbreviation:  Farmaco     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-06-18     Completed Date:  1993-06-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8912641     Medline TA:  Farmaco     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  143-50     Citation Subset:  IM    
Affiliation:
Menarini Richerche Sud, Pomezia Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / chemical synthesis*,  metabolism,  pharmacology
Cattle
DNA / drug effects,  metabolism*
Oligopeptides / chemical synthesis*,  metabolism,  pharmacology
Pyrroles / chemical synthesis*,  metabolism,  pharmacology
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Oligopeptides; 0/Pyrroles; 9007-49-2/DNA

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