| Synthesis and DNA binding selectivity of pyrrole-amidine oligopeptides. | |
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MedLine Citation:
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PMID: 8494595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A class of DNA binding antibiotics endowed with antiviral and antitumor properties is reviewed. Starting from the original natural products, namely distamycin and netropsin, new compounds have been recently synthesized with the aim to obtain agents with specific affinity for defined DNA sequences and with different interaction mechanism (reversible or irreversible). |
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Authors:
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F Arcamone |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Farmaco (Società chimica italiana : 1989) Volume: 48 ISSN: 0014-827X ISO Abbreviation: Farmaco Publication Date: 1993 Feb |
Date Detail:
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Created Date: 1993-06-18 Completed Date: 1993-06-18 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8912641 Medline TA: Farmaco Country: ITALY |
Other Details:
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Languages: eng Pagination: 143-50 Citation Subset: IM |
Affiliation:
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Menarini Richerche Sud, Pomezia Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / chemical synthesis*, metabolism, pharmacology Cattle DNA / drug effects, metabolism* Oligopeptides / chemical synthesis*, metabolism, pharmacology Pyrroles / chemical synthesis*, metabolism, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Oligopeptides; 0/Pyrroles; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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