Document Detail


Synthesis, Cytotoxicity and Cell Death Profile of Polyaminoanthraquinones as Antitumor Agents.
MedLine Citation:
PMID:  22913275     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Investigation on designed polyaminoanthraquinones revealed that the anthraquinones bearing triamine motifs are generally more potent than their counterparts with diamine or tetraamine motifs. Compared to the reference drug Mitoxantrone (MTX), 9b and 9c exhibited better inhibitory activity on cancerous HepG2 cells and preferable cell selectivity in the further screen of normal QSG7701 cells, although they were not assimilated by cancer cells via the polyamine transporter. The presence of polyamine motifs elevated the interaction of compounds 9b and 9c with lysosomes, and resulted in distinct mode of cell death. 9c and MTX could cause caspases-dependent HepG2 cell apoptotic death involving in mitochondria membrane potential (MMP) loss, cytochrome c release and caspase-3 activation. However, 9b, which contained only one less methylene group in the polyamine tail, produced cytotoxicity by necrosis. In conclusion, the modification of anthraquinones with polyamines may furnish potent anticancer drug candidates against hepatocellular carcinoma undergoing distinct cell death mechanisms. © 2012 John Wiley & Sons A/S.
Authors:
Jianhong Wang; Ruihong Gao; Qian Li; Songqiang Xie; Jin Zhao; Chaojie Wang
Related Documents :
11099875 - Concordant in situ and in vitro data show that maternal cigarette smoking negatively re...
12397615 - Proliferation marker pki-67 affects the cell cycle in a self-regulated manner.
14593745 - Roles and regulation of serine/threonine-specific protein phosphatases in the cell cycle.
402125 - Synchronization of anacystis nidulans. oxygen evolution during the cell cycle.
24525555 - Recent advancements in optofluidics-based single-cell analysis: optical on-chip cellula...
9753085 - Spatial organization of proprioception in the cat spinocerebellum. purkinje cell respon...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-22
Journal Detail:
Title:  Chemical biology & drug design     Volume:  -     ISSN:  1747-0285     ISO Abbreviation:  Chem Biol Drug Des     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262549     Medline TA:  Chem Biol Drug Des     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng 475004, China Institute of Chemistry and Biology, Henan University, Kaifeng 475004, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  What are patient factors associated with the quality of diabetes care?: results from the Korean Nati...
Next Document:  Effects of amn?ot?c and maternal CD-146, TGF-?1, IL-12, IL-18 and Inf-?, on adverse pregnancy outcom...