Document Detail


Synthesis and characterization of hybrid hyaluronic acid-gelatin hydrogels.
MedLine Citation:
PMID:  23419055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biomimetic hybrid hydrogels have generated broad interest in tissue engineering and regenerative medicine. Hyaluronic acid (HA) and gelatin (hydrolyzed collagen) are naturally derived polymers and biodegradable under physiological conditions. Moreover, collagen and HA are major components of the extracellular matrix (ECM) in most of the tissues (e.g., cardiovascular, cartilage, neural). When used as a hybrid material, HA-gelatin hydrogels may enable mimicking the ECM of native tissues. Although HA-gelatin hybrid hydrogels are promising biomimetic substrates, their material properties have not been thoroughly characterized in the literature. Herein, we generated hybrid hydrogels with tunable physical and biological properties by using different concentrations of HA and gelatin. The physical properties of the fabricated hydrogels including swelling ratio, degradation, and mechanical properties were investigated. In addition, in vitro cellular responses in both two and three-dimensional culture conditions were assessed. It was found that the addition of gelatin methacrylate (GelMA) into HA methacrylate (HAMA) promoted cell spreading in the hybrid hydogels. Moreover, the hybrid hydrogels showed significantly improved mechanical properties compared to their single component analogs. The HAMA-GelMA hydrogels exhibited remarkable tunability behavior and may be useful for cardiovascular tissue engineering applications.
Authors:
Gulden Camci-Unal; Davide Cuttica; Nasim Annabi; Danilo Demarchi; Ali Khademhosseini
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-03-28
Journal Detail:
Title:  Biomacromolecules     Volume:  14     ISSN:  1526-4602     ISO Abbreviation:  Biomacromolecules     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-08     Completed Date:  2013-09-26     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1085-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biocompatible Materials / chemistry
Biomimetics
Cell Adhesion
Cells, Cultured
Gelatin / chemistry*
Human Umbilical Vein Endothelial Cells / metabolism*
Humans
Hyaluronic Acid / chemistry*
Hydrogels* / chemical synthesis,  chemistry,  metabolism
Methacrylates / chemistry
Regenerative Medicine
Tissue Engineering
Tissue Scaffolds
Grant Support
ID/Acronym/Agency:
AR057837/AR/NIAMS NIH HHS; DE019024/DE/NIDCR NIH HHS; DE021468/DE/NIDCR NIH HHS; EB008392/EB/NIBIB NIH HHS; EB012597/EB/NIBIB NIH HHS; HL092836/HL/NHLBI NIH HHS; HL099073/HL/NHLBI NIH HHS; R01 AR057837/AR/NIAMS NIH HHS; R01 DE021468/DE/NIDCR NIH HHS; R01 EB008392/EB/NIBIB NIH HHS; R01 EB012597/EB/NIBIB NIH HHS; R01 HL092836/HL/NHLBI NIH HHS; R01 HL099073/HL/NHLBI NIH HHS; RL1 DE019024/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Hydrogels; 0/Methacrylates; 9000-70-8/Gelatin; 9004-61-9/Hyaluronic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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