Document Detail

Synthesis of C-6-substituted uridine phosphonates through aerobic ligand-free Suzuki-Miyaura cross-coupling.
MedLine Citation:
PMID:  20856988     Owner:  NLM     Status:  In-Process    
An efficient protocol for the construction of C-6-(hetero)aryl-substituted uridine phosphonate analogues utilizing an aerobic, ligand-free Suzuki-Miyaura cross-coupling reaction of a 6-iodo-precursor in aqueous media has been established. The method presents a modular approach toward the target compounds as demonstrated by the synthesis of a small library comprising 14 novel nucleoside phosphonates.
Radim Nencka; Davy Sinnaeve; Izet Karalic; José C Martins; Serge Van Calenbergh
Related Documents :
11594818 - A novel one-pot pyrrole synthesis via a coupling-isomerization-stetter-paal-knorr seque...
10458808 - A one-pot, one-operation
15675868 - Synthesis of 4-aryl-2-pyrrolidones and beta-aryl-gamma-amino-butyric acid (gaba) analog...
12688768 - Nickel 0-catalyzed cross-coupling of alkyl arenesulfonates with aryl grignard reagents.
547228 - Facile syntheses of 1,2,4-triazole and s-triazine glycosides from glycosyl isothiocyana...
22159268 - Direct preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from al...
Publication Detail:
Type:  Journal Article     Date:  2010-09-21
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  8     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  5234-46     Citation Subset:  IM    
Laboratory for Medicinal Chemistry, Faculty of Pharmaceutical Sciences (FFW), Ghent University, Harelbekestraat 72, B-9000, Ghent, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cyclen-hybrid compound captures copper to protect INS-1 cells from islet amyloid polypeptide cytotox...
Next Document:  Carbene-carbanion equilibrium for tris(2-pyridylthio)methanido Fe(II) complexes.