| Synthesis, Biological Evaluation, and Structure-Activity Relationships of 2-[2-(Benzoylamino)benzoylamino]-benzoic Acid Analogs as Inhibitors of Adenovirus Replication. | |
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MedLine Citation:
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PMID: 22369233 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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2-[2-Benzoylamino)benzoylamino]-benzoic acid (1) was previously identified as a potent and non-toxic anti-adenoviral compound1. Here, the potency of 1 was improved over three generations of compounds. We found that the ortho, ortho substituent pattern and the presence of the carboxylic acid of 1 are favorable for this class of compounds, and that the direction of the amide bonds (as in 1) is obligatory. Some variability in the N-terminal moiety was tolerated, but benzamides appear to be preferred. The substituents on the middle and C-terminal rings were varied, resulting in two potent inhibitors, 35g and 35j, with EC50 = 0.6 μM and low cell toxicity. |
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Authors:
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Christopher T Oberg; Mårten Strand; Emma K Andersson; Karin Edlund; Nam Phuong Nguyen Tran; Ya-Fang Mei; Göran Wadell; Mikael Elofsson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-27 |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: - ISSN: 1520-4804 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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