Document Detail

Synthesis, Biological Evaluation, and Structure-Activity Relationships of 2-[2-(Benzoylamino)benzoylamino]-benzoic Acid Analogs as Inhibitors of Adenovirus Replication.
MedLine Citation:
PMID:  22369233     Owner:  NLM     Status:  Publisher    
2-[2-Benzoylamino)benzoylamino]-benzoic acid (1) was previously identified as a potent and non-toxic anti-adenoviral compound1. Here, the potency of 1 was improved over three generations of compounds. We found that the ortho, ortho substituent pattern and the presence of the carboxylic acid of 1 are favorable for this class of compounds, and that the direction of the amide bonds (as in 1) is obligatory. Some variability in the N-terminal moiety was tolerated, but benzamides appear to be preferred. The substituents on the middle and C-terminal rings were varied, resulting in two potent inhibitors, 35g and 35j, with EC50 = 0.6 μM and low cell toxicity.
Christopher T Oberg; Mårten Strand; Emma K Andersson; Karin Edlund; Nam Phuong Nguyen Tran; Ya-Fang Mei; Göran Wadell; Mikael Elofsson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-27
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  -     ISSN:  1520-4804     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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