| Synthesis and Biological Evaluation of Ezetimibe Analogs as Possible Cholesterol Absorption Inhibitors. | |
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MedLine Citation:
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PMID: 21966284 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In order to investigate the SAR of Ezetimibe analogs for cholesterol absorption inhibitions, amide group and electron-deficient pyridine ring were introduced to the C-(3) carbon chain of Ezetimibe. Eight new derivatives of the 2-azetidinone cholesterol absorption inhibitors have been synthesized, and all of them were enantiomerically pure. All the new compounds were evaluated for their activity to inhibit cholesterol absorption in hamsters, and most of them showed comparable effects in lowering the levels of total cholesterol in the serum. |
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Authors:
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Yubin Wang; Haiqian; Wenlong Huang; Huibin Zhang; Jinpei Zhou |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Letters in drug design & discovery Volume: 8 ISSN: 1570-1808 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-10-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208443 Medline TA: Lett Drug Des Discov Country: - |
Other Details:
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Languages: ENG Pagination: 500-505 Citation Subset: - |
Affiliation:
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School of Pharmaceutical Sciences, Nanjing University of Technology, NO.5 Xinmofan Road, Nanjing 210009, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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