Document Detail


Synthesis and Biological Evaluation of 3-Substituted-4-(4-methylthio phenyl)-1H-Pyrrole Derivatives as Potential Anticancer Agents.
MedLine Citation:
PMID:  24372525     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A novel series of 3-substituted-4-(4-methylthio phenyl)-1H-pyrrole derivatives were synthesized via Van Leusen pyrrole synthesis. The in vitro anticancer activity against a panel of 16 cancer cell lines and 2 normal cell lines was investigated by MTT assay. It was found that some of the pyrrole compounds showed similar antiproliferative activity against cancer cells compared with Paclitaxel, but little impact on normal cell lines, which indicated that the novel pyrrole derivatives could be used as potential anticancer candidates for possessing both selectivity and good therapeutic efficacy. Structure-activity relationship analysis found that 3-phenylacetyl-4-(4-methylthio phenyl)-1H-pyrrole derivatives displayed the most strong anticancer activity, among which [4-(4-methylthio phenyl)-1H-pyrrol-3-yl] (4-methoxy phenyl) methanone (3j) was employed to investigate the effect of these pyrrole analogues on cell cycle by propidium iodide (PI) staining on cell flow cytometry. Cell necrotic effect of 10.0 µM 3j against MGC80-3 cells were also observed under fluorescence microscope and transmission electron microscope by ultrathin sections observation.
Authors:
Lan Lan; Weixi Qin; Xiaoping Zhan; Zenglu Liu; Zhenmin Mao
Related Documents :
24472895 - On-chip self-assembly of cell embedded microstructures to vascular-like microtubes.
23149915 - Bcl3 selectively promotes metastasis of erbb2-driven mammary tumours.
24859355 - Sodium arsenite induces ros-dependent autophagic cell death in pancreatic β-cells.
23672235 - The antifungal occidiofungin triggers an apoptotic mechanism of cell death in yeast.
2208115 - Increased sensitivity to vinca alkaloids in cells overexpressing calmodulin by gene tra...
2924775 - In vivo 31p- and 13c-nmr studies of atp synthesis and methane formation by methanosarci...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-24
Journal Detail:
Title:  Anti-cancer agents in medicinal chemistry     Volume:  -     ISSN:  1875-5992     ISO Abbreviation:  Anticancer Agents Med Chem     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265649     Medline TA:  Anticancer Agents Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  White Blood Cell Subtypes, Insulin Resistance and ?-cell Dysfunction in High Risk Individuals - the ...
Next Document:  Sesamol Ameliorates Cyclophosphamide-Induced Hepatotoxicity by Modulating Oxidative Stress and Infla...