Document Detail

Synthesis of Biodegradable Amphiphilic Y-shaped Block Co-polymers via Ring-Opening Polymerization for Drug Delivery.
MedLine Citation:
PMID:  20615355     Owner:  NLM     Status:  Publisher    
A series of novel Y-shaped biodegradable block co-polymers of poly(varepsilon-caprolactone) (PCL) and poly(ethyl ethylene phosphate) (PEEP) (PCL-(PEEP)(2)) were synthesized via ring-opening polymerization (ROP) of EEP with bis-hydroxy-functional ROP initiator (init-PCL-(OH)(2)). The init-PCL-(OH)(2) was synthesized by ROP of CL using 4-hydroxybutyl acrylate (HBA) as initiator and L-tartaric acid as catalyst in bulk, and subsequently the resulting vinyl-terminated PCL was end-capped by acetyl chloride, followed by Michael addition using excess diethanolamine. The Y-shaped co-polymers and their intermediates were characterized by (1)H-, (13)C-, (31)P-NMR, FT-IR and gel-permeation chromatography. The results indicated that the molecular weight of the Y-shaped co-polymers increased with the increasing of the molar ratios of EEP to init-PCL-(OH)(2) in the feed, while the PCL chain length was kept constant. The amphiphilic block co-polymers could self-assemble into micelles in aqueous solution, which was demonstrated by dynamic light scattering, (1)H-NMR and atomic force microscopy. A study of controlled release of indomethacin indicated that the amphiphilic block co-polymers could potentially provide novel vehicles for drug delivery.
Lin Jia; Lifeng Yan; Yang Li
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-7-2
Journal Detail:
Title:  Journal of biomaterials science. Polymer edition     Volume:  -     ISSN:  1568-5624     ISO Abbreviation:  -     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-7-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007393     Medline TA:  J Biomater Sci Polym Ed     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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