| Synthesis of Biodegradable Amphiphilic Y-shaped Block Co-polymers via Ring-Opening Polymerization for Drug Delivery. | |
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MedLine Citation:
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PMID: 20615355 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A series of novel Y-shaped biodegradable block co-polymers of poly(varepsilon-caprolactone) (PCL) and poly(ethyl ethylene phosphate) (PEEP) (PCL-(PEEP)(2)) were synthesized via ring-opening polymerization (ROP) of EEP with bis-hydroxy-functional ROP initiator (init-PCL-(OH)(2)). The init-PCL-(OH)(2) was synthesized by ROP of CL using 4-hydroxybutyl acrylate (HBA) as initiator and L-tartaric acid as catalyst in bulk, and subsequently the resulting vinyl-terminated PCL was end-capped by acetyl chloride, followed by Michael addition using excess diethanolamine. The Y-shaped co-polymers and their intermediates were characterized by (1)H-, (13)C-, (31)P-NMR, FT-IR and gel-permeation chromatography. The results indicated that the molecular weight of the Y-shaped co-polymers increased with the increasing of the molar ratios of EEP to init-PCL-(OH)(2) in the feed, while the PCL chain length was kept constant. The amphiphilic block co-polymers could self-assemble into micelles in aqueous solution, which was demonstrated by dynamic light scattering, (1)H-NMR and atomic force microscopy. A study of controlled release of indomethacin indicated that the amphiphilic block co-polymers could potentially provide novel vehicles for drug delivery. |
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Authors:
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Lin Jia; Lifeng Yan; Yang Li |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-7-2 |
Journal Detail:
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Title: Journal of biomaterials science. Polymer edition Volume: - ISSN: 1568-5624 ISO Abbreviation: - Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-7-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007393 Medline TA: J Biomater Sci Polym Ed Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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