| Synthesis of Biocompatible, Mesoporous Fe(3)O(4) Nano/Microspheres with Large Surface Area for Magnetic Resonance Imaging and Therapeutic Applications. | |
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MedLine Citation:
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PMID: 21229966 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This article reports the fabrication of mesoporous Fe(3)O(4) nano/microspheres with a high surface area value (163 m(2)/g, Brunauer-Emmett-Teller) and demonstrates their use for drug loading, release, and magnetic resonance imaging (MRI). These monodispersed, mesoporous Fe(3)O(4) nano/microspheres with controllable average sizes ranging from 50 to 200 nm were synthesized using a Fe(3)O(4)/poly(acrylic acid) hybrid sphere template and subsequent silica shell formation and removal. We found that the SiO(2) coating is a crucial step for the successful synthesis of uniform mesoporous Fe(3)O(4) nano/microspheres. The as-synthesized mesoporous Fe(3)O(4) nanospheres show a high magnetic saturation value (M(s) = 48.6 emu/g) and could be used as MRI contrast agents (r(2) = 36.3 s(-1) mM(-1)). Trypan blue exclusion and MTT assay (see Supporting Information ) cytotoxicity analyses of the nanospheres based on HepG2 and MDCK cells showed that the products were biocompatible, with a lower toxicity than lipofectamine (positive control). Hydrophilic ibuprofen and hydrophobic zinc(II) phthalocyanine drug loading into mesoporous Fe(3)O(4) nanospheres and selected release experiments were successfully achieved. The potential use of mesoporous Fe(3)O(4) nanospheres in biomedical applications, in light of the nano/microspheres' efficient drug loading and release, MRI, and low cytotoxicity, has been demonstrated. It is envisaged that mesoporous Fe(3)O(4) nanospheres can be used as drug carriers and MRI contrast agents for the reticuloendothelial system; they can also be delivered locally, such as via a selective catheter. |
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Authors:
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Shouhu Xuan; Feng Wang; Josie M Y Lai; Kathy W Y Sham; Yi-Xiang J Wang; Siu-Fung Lee; Jimmy C Yu; Christopher H K Cheng; Ken Cham-Fai Leung |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-13 |
Journal Detail:
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Title: ACS applied materials & interfaces Volume: - ISSN: 1944-8244 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101504991 Medline TA: ACS Appl Mater Interfaces Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Center of Novel Functional Molecules and Institute of Molecular Functional Materials, Department of Chemistry, § School of Biomedical Sciences, and ⊥ Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong , Shatin, NT, Hong Kong SAR, People's Republic of China. |
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