| Synthesis of BMS-309403-Related Compounds, Including [(14)C]BMS-309403, a Radioligand for Adipocyte Fatty Acid Binding Protein. | |
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MedLine Citation:
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PMID: 22223390 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Adipocyte fatty acid binding protein (A-FABP; FABP4), which is predominantly expressed in macrophages and adipose tissue, regulates fatty acid storage and lipolysis, and is also an important mediator of inflammation. Here, we report a synthesis of (14)C-labeled 2-[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)biphenyl-3-yloxy]acetic acid (BMS309403), a potent and selective small-molecular FABP4 inhibitor, as a chemical tool for investigating the roles of FABP4 in inflammatory and metabolic disorders. The structure-activity relationship of several BMS derivatives for inhibition of FABP4 is also reported. |
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Authors:
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Toshihiko Okada; Makoto Hiromura; Masato Otsuka; Shuichi Enomoto; Hiroyuki Miyachi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 60 ISSN: 1347-5223 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 164-8 Citation Subset: IM |
Affiliation:
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Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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