Document Detail


Synthesis of axially chiral amino acid and amino alcohols via additive-ligand-free Pd-catalyzed domino coupling reaction and subsequent transformations of the product amidoaza[5]helicene.
MedLine Citation:
PMID:  20839825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Novel optically active axially chiral amino acid and amino alcohols have been synthesized efficiently via lactam ring-opening, with the aid of an optically active alcohol, amidoaza[5]helicene 5, which has been readily prepared by an additive-ligand-free Pd catalyzed domino coupling reaction in a single step. The stereostructures of these chiral molecules have also been clarified.
Authors:
Takumi Furuta; Junya Yamamoto; Yuki Kitamura; Ayano Hashimoto; Hyuma Masu; Isao Azumaya; Toshiyuki Kan; Takeo Kawabata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  75     ISSN:  1520-6904     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-08     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7010-3     Citation Subset:  IM    
Affiliation:
Institute for Chemical Research, Kyoto University, Uji 611-0011, Kyoto, Japan. furuta@fos.kuicr.kyoto-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Amides / chemistry*
Amino Acids / chemical synthesis*,  chemistry
Amino Alcohols / chemical synthesis*,  chemistry
Ligands
Molecular Structure
Organometallic Compounds / chemistry*
Palladium / chemistry*
Stereoisomerism
Chemical
Reg. No./Substance:
0/Amides; 0/Amino Acids; 0/Amino Alcohols; 0/Ligands; 0/Organometallic Compounds; 7440-05-3/Palladium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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