Document Detail


Synthesis of Arabino glycosyl triazoles as potential inhibitors of mycobacterial cell wall biosynthesis.
MedLine Citation:
PMID:  18926698     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of arabino glycosyl triazoles with varying hydrophobic groups were synthesised as putative mimics of decaprenolphosphoarabinose (DPA) as potential inhibitors of mycobacterial cell wall biosynthesis. Biological testing against Mycobacterium bovis BCG revealed low to moderate anti-mycobacterial activity, with strong dependence on the identity of the hydrophobic side chain.
Authors:
Brendan L Wilkinson; Hilary Long; Edith Sim; Antony J Fairbanks
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-26
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  18     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-13     Completed Date:  2009-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  6265-7     Citation Subset:  IM    
Affiliation:
Department of Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
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MeSH Terms
Descriptor/Qualifier:
Antitubercular Agents / chemical synthesis*,  pharmacology*
Arabinose / analogs & derivatives,  chemical synthesis*,  pharmacology*
Cell Wall / drug effects,  metabolism
Glycosides / chemical synthesis*,  chemistry,  pharmacology*
Isoniazid / pharmacology
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium bovis / drug effects*,  metabolism
Structure-Activity Relationship
Triazoles / chemical synthesis*,  chemistry,  pharmacology*
Chemical
Reg. No./Substance:
0/Antitubercular Agents; 0/Glycosides; 0/Triazoles; 147-81-9/Arabinose; 54-85-3/Isoniazid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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