| Synthesis, Antiviral and Cytotoxic Activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one Derivatives. | |
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MedLine Citation:
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PMID: 21969760 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and anthranilic acid. Synthesized compounds were evaluated for in vitro antiviral activity against HIV, HSV and vaccinia viruses. 5-Bromo-2-(6-bromo-4-oxo-2-phenyl-4H-quinazolin-3-yl)-benzoic acid (MBR2) exhibited distinct antiviral activity against Herpes simplex and vaccinia viruses. |
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Authors:
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P Selvam; N Murugesh; M Chandramohan; C Pannecouque; E DE Clercq |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of pharmaceutical sciences Volume: 72 ISSN: 1998-3743 ISO Abbreviation: Indian J Pharm Sci Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2011-10-04 Completed Date: 2011-11-10 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 7809431 Medline TA: Indian J Pharm Sci Country: India |
Other Details:
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Languages: eng Pagination: 806-9 Citation Subset: - |
Affiliation:
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Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malapuram - 673 436, India. |
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